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Virulence in mice: organ titers and LD50
| Virus | Average virus titer per organ (log10 PFU) ± SD (no. of virus-positive organs/total no. of organs) |
LD50 (PFU) | ||
|---|---|---|---|---|
| Lung | Heart | Brain | ||
| R65 | 6.6 ± 0.1 (3/3) | 2.6 ± 2.6 (2/3) | 2.7 ± 0.3 (2/3) | <10 |
| R65-PB2K627E | 4.6 ± 0.4 (3/3) | 3.0 (1/3) | 0 (0/3) | >104 |
