Fig. 9.
HIV-1 gp120-specific total IgG serum antibody responses in guinea pigs. The guinea pigs were immunized with rNDVs by the different routes described for Fig. 7. Mean ELISA endpoint titers of gp120-binding total IgG serum antibodies from days 14, 21, 28, 35, and 42 are shown. i.m.-i.m., i.n.-i.n., i.n.-i.m., and i.m.-i.n. indicate guinea pig groups rLasota/gp160 i.m.-i.m., rLasota/gp160 i.n.-i.n., rLasota/gp160 i.n.-i.m., and rLasota/gp160 i.m.-i.n., respectively. Antibodies specific for gp120 were not detected in any animal on any day in either control group (rLaSota i.n.-i.n. and i.m.-i.m.). The graph shows the geometric mean values ± SEM for the 3 animals in each group. Statistical differences between the groups were calculated by one-way ANOVA (P < 0.05). Arrows indicate times of rNDV immunizations on days 0, 14, and 28.