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Proposed equilibrium model of c-Src activity regulation. Cbp and Cav-1 recruit cytoplasmic Csk to the membrane, where Csk mediates inactivation of c-Src. If one adapter is absent or not functional, there is a compensatory increase in the other to enable coordination of Csk and negative regulation of c-Src activity. This model also predicts that when both Csk adapters are absent or nonfunctional, Csk is unable to localize to the membrane, resulting in sustained c-Src activation.
