Fig. 6.

Sodium channel inhibitors decrease persistent currents. A, persistent current values for WT, T1464I, and M1627K channels in the presence of the different sodium channel inhibitors. Data are presented as the mean percentage of the peak transient current. B, normalized current traces elicited by a step depolarization to +20 mV from representative WT or PEPD mutant channels as indicated by arrows. Persistent current amplitudes were measured relative to leak-subtracted baseline and averaged over the last 5 ms of the pulse as indicated by the shaded region. C, the average resurgent current amplitude relative to DMSO for each channel construct at each drug concentration tested is plotted against the respective persistent current amplitude (as shown in A) relative to DMSO and fitted with a linear trendline. *, p < 0.05 from DMSO by student's unpaired t test. n = 7 to 10 cells each condition. All recordings were done with the Navβ4 peptide in the intracellular solution.