Table 3.
Language functions on healthy controls (when available) and primary progressive aphasia subtypes
| Healthy controls | Non-fluent variant | Semantic variant | Logopenic variant | Model | |
|---|---|---|---|---|---|
| Language production | |||||
| Boston naming test (15) | 14.6 (0.7) | 10.8 (4.5)* | 1.7 (0.9)***a,c | 10.0 (4.8)** | *** |
| Phonemic fluency | 18.1 (4.2) | 5.8 (3.6)*** | 3.0 (2.6)***c | 9.0 (5.9)*** | *** |
| Semantic fluency (animals) | 23.19 (5.2) | 9.0 (6.1)*** | 3.8 (3.0)*** | 9.1 (4.3)*** | *** |
| Speech fluency (WAB, 10) | 5.0 (2.6)a,b | 7.5 (1.2) | 8.2 (1.7) | ** | |
| Repetition (WAB, 100) | 80.0 (9.5) | 76.4 (14.0) | 72.2 (16.1) | NS | |
| Motor speech | |||||
| Apraxia of speech rating (MSE, 7) | 3.1 (2.0)b,c | 0.0 (0.0) | 0.0 (0.0) | *** | |
| Dysarthria rating (MSE, 7) | 2.4 (3.2)b | 0.0 (0.0) | 0.0 (0.0) | * | |
| Single-word comprehension and semantic function | |||||
| PPVT (16) | 15.8 (0.4) | 14.0 (2.1) | 4.1 (2.8)***a,c | 13.4 (2.4)* | *** |
| Word recognition (WAB, 60) | 59.1 (1.7) | 47.7 (7.8)a,c | 58.2 (3.5) | *** | |
| PPTP (52) | 48.8 (2.4) | 38.9 (8.5)a,c | 50.0 (1.8) | *** | |
| Sentence comprehension | |||||
| CYCLE Raw | 41.8 (8.6) | 44.4 (9.7) | 46.2 (5.8) | NS | |
| CYCLE Per cent | 75.8 (15.8) | 80.6 (17.8) | 83.8 (10.6) | NS |
Values shown are mean (SD). Asterisks denote significantly impaired (or different) relative to healthy controls at *P < 0.05; **P < 0.01; ***P < 0.001. Superscript letters denote significantly impaired (or different, in the case of demographic data) relative to the anon-fluent, bsemantic and clogopenic variants at P < 0.05. Univariate ANOVAs were used to compare the different groups when not else specified.
CYCLE = Curtiss-Yamada Comprehensive Language Examination; MSE = Motor Speech Evaluation (Wertz et al., 1984); PPTP = Pyramids and Palm trees pictures; PPVT = Peabody Picture Vocabulary Test; WAB = Western Aphasia Battery; NS = not significant.