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. Author manuscript; available in PMC: 2011 Oct 5.
Published in final edited form as: Nature. 2010 Apr 1;464(7289):757–762. doi: 10.1038/nature08819

Figure 5. Transcriptional control network in area X engaged by singing.

Figure 5

a, Clustered (1–20) temporal expression profiles of 807 genes (rows) that change with time and amount of singing; red, increases; blue, decreases; white, no change relative to average 0-h control. Grey/coloured bars on left, clusters with enrichment of specific promoter motifs (P < 0.01). b, Enriched transcription-factor-binding motifs (abbreviations) found in the promoters of late response genes, clusters 9–12 (coloured as in a); bold, binding sites for known activity-dependent transcription factors (for example, CREBP1) or transcription factor complexes (for example, CREBP1–CJUN); black, sites for post-translationally activated transcription factors; brown, sites for transcriptionally activated transcription factors including by singing (for example, in cluster 1). Graph shows time course of average expression of all genes in the late response clusters, normalized to average 0 h for that cluster. Also plotted is the average expression of the C-FOS transcription factor mRNA, which binds to the AP-1 site over-represented in the promoters of cluster 10 genes.