Table 1.
Compd | IC50 [μm] | Ratio | |
---|---|---|---|
PI3Kα | PI3Kγ | α/γ | |
1 | 4.5 | 0.30 | 18 |
2 | 0.060 | 0.0080 | 7.5 |
3 | 0.050 | 0.040 | 1.3 |
4 | 0.25 | 0.10 | 2.5 |
5 | 0.45 | 0.12 | 3.8 |
6 | 50 | >100 | <0.50 |
7 | 1.9 | 1.0 | 1.9 |
8 | 7.3 | 27 | 0.30 |
9 | 4.4 | 9.3 | 0.50 |
10 | 2.7 | 4.9 | 0.60 |
11 | 0.069 | 0.042 | 1.6 |
12 | 0.15 | 0.12 | 1.2 |
13 | 2.7 | 0.25 | 11 |
14 | 11 | 1.5 | 7.1 |
15 | 9.4 | 3.1 | 3.1 |
16 | 86 | 4.0 | 22 |
17 | 22 | 1.4 | 16 |
19 | 0.0030 | 0.0013 | 2.2 |
20 | 8.3 | 0.62 | 13 |
40 | 3.0 | 0.41 | 7.3 |
41 | 11 | 1.4 | 7.9 |
42 | 0.14 | 0.060 | 2.3 |
43 | 8.7 | >100 | <0.087 |
44 | 9.0 | >100 | <0.090 |
45 | 0.40 | 0.20 | 2.0 |
46 | 0.10 | 0.025 | 4.0 |
47 | 0.80 | 1.0 | 0.80 |