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. 2011 Nov;4(6):375–389. doi: 10.1177/1756283X11413315

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Figure 1. — Comparative structures of the anti-TNF agents infliximab, adalimumab and certolizumab pegol. Infliximab is a chimeric IgG1 monoclonal antibody, the Fc’ portion of which is human. Adalimumab is a human IgG1 monoclonal antibody. Certolizumab pegol is a human monoclonal antibody Fab′ conjugated with polyethylene glycol (PEG), an inert 40-kDa macromolecule used to enhance the pharmacokinetic properties of biologics. Adapted with permission from Adis Data Information BV [Bourne et al. 2008, 22(5): 331–337], copyright © 2008.