Figure 4.

Improvement in work productivity with certolizumab pegol in PRECiSE 2. Mean changes in Work Productivity and Activities Index in Crohn’s disease (WPAI:CD) scores and 95% confidence interval (within-treatment) (A) at week 26 from week 6 (maintenance phase) and (B) at week 26 from baseline (induction and maintenance). *p < 0.05. **p < 0.001; comparisons within treatment groups for week 6 versus week 26 (a) and week 0 versus week 26 (b) are by paired t-test (change significantly different from 0). ^†p < 0.05, ^††p < 0.01, ^†††p < 0.001; comparisons between the two treatment arms are by Student’s t-test. A larger negative change means greater improvement for each parameter. Reprinted with permission from Blackwell Publishing Ltd [Feagan et al. 2010, pp. 1276–1285], copyright © 2010.