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. 2011 Sep 15;3(9):1739–1756. doi: 10.3390/v3091739

Figure 1.

Figure 1.

Schematic representation of the Dengue virus (DENV) genome. (a) The viral 5′ and 3′ untranslated regions (UTRs) and the open reading frame indicating structural proteins (C-prM-E) and non-structural proteins (NS1-NS2AB-NS3-NS4AB-NS5). The location of the complementary sequences 5′-3′CS and 5′-3′UAR are also indicated by solid and dashed lines, respectively. (b) Predicted secondary structure of the 5′ terminal region of the DENV genome. Structural elements located at the 5′ end: stem loop A (SLA), stem loop B (SLB), oligo(U) track spacer, translation initiator AUG, capsid region hairpin (cHP), and the 5′CS element. (c) Schematic representation of predicted RNA elements at the 3′UTR of the DENV genome. The predicted secondary structures of the three defined domains are indicated: domain I (variable region, VR), domain II (dumbbell structures, DB1 and DB2), and domain III (conserved sequence CS1 and 3′SL). In addition, the location and sequence of each of the conserved elements corresponding to RCS2, CS2, 3′CS, and 3′UAR are shown.