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. 2011 Oct 3;195(1):41–54. doi: 10.1083/jcb.201103117

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© 2011 Lin et al.

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Figure 3. — TMS3 control of RTC structure. (A) The entry of TMS2 into the ribosome tunnel closes the RTC junction and opens the lumenal end of the pore (i). When TMS3 moves into the tunnel, does the RTC junction open and the lumenal end of the pore close (ii)? The lumenal loop sequence after TMS2 is shown in black, whereas the cytosolic loop sequences after TMS1 and TMS3 are shown in red for the full-length PMP (iii). (B and G) Protein primary structures are depicted to show the locations of topogenic sequences and the single lysine codon (red) in each. TMS3 = opsin 3 (magenta); others are as in Fig. 2 A. (C and D) Collisional quenching data for RTCs with the indicated nascent chains obtained before (red ▴) or after (black •) MLT addition. The straight lines coincide in D. (E, F, H, I, and J) Bar graphs show the ΔK_sv values for the indicated nascent chain lengths of the indicated proteins. Standard deviations and n values are shown in Table II. Error bars indicate SD.