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. 2011 Sep 24;11:405. doi: 10.1186/1471-2407-11-405

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Copyright ©2011 Sernbo et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Promoter methylation of SOX11 correlates to mRNA and protein expression in EOC cell lines. The relative mRNA levels (RQ) as compared to OVCAR-3 are shown as diamonds. The standard deviation for the RQ values has been calculated with a 95% confidence interval (CI). Below, corresponding protein levels are shown. The degree of SOX11 promoter methylation, described as percentage of methylated CpGs of 28 possible CpG methylation sites, is shown as bars. The three cell lines A2780, A2780-CP7 and ES-2 all lack mRNA and protein expression of SOX11, correlating to a high percentage of methylated CpG sites.