Table 1.
Clinical and demographic characteristics of subjects in CAPS
| Characteristics | # (%) of cases
|
# (%) of controls (N=1,722) | ||
|---|---|---|---|---|
| Aggressive (N=1,231) | Non-aggressive (N=1,619) | All cases (N=2,899) | ||
| Age at enrollment (Year) | ||||
| Mean (sd) | 68.04 (7.32) | 65.14 (6.74) | 66.36 (7.13) | 67.15 (7.39) |
| Age at disgnosis | ||||
| ≤ 65 | 514 (41.75) | 926 (57.19) | 1469 (50.78) | N/A |
| > 65 | 717 (58.25) | 693 (42.81) | 1424 (49.22) | N/A |
| Family History (first-degree relatives) | ||||
| No | 1013 (82.29) | 1295 (79.99) | 2342 (80.95) | 1565 (90.57) |
| Yes | 218 (17.71) | 324 (20.01) | 551 (19.05) | 163 (9.43) |
| Missing data | 0 | 0 | 0 | 0 |
| PSA levels at diagnosis for cases or at enrollment for controls (ng/ml) | ||||
| ≤ 4 | 36 (2.95) | 185 (11.61) | 221 (7.85) | 1438 (83.56) |
| 5–9.99 | 171 (14.00) | 755 (47.39) | 926 (32.91) | 230 (13.36) |
| 10–19.99 | 216 (17.69) | 438 (27.50) | 654 (23.24) | 37 (2.15) |
| 20–49.99 | 252 (20.64) | 215 (13.50) | 467 (16.60) | 13 (0.76) |
| 50–99.99 | 229 (18.76) | 0 | 229 (8.14) | 2 (0.12) |
| ≥ 100 | 317 (25.96) | 0 | 317 (11.27) | 1 (0.06) |
| Missing | 10 | 26 | 85 | 1 |
| T-stage | ||||
| T0 | 2 (0.16) | 7 (0.44) | 9 (0.32) | N/A |
| T1 | 147 (12.07) | 933 (58.24) | 1080 (38.30) | N/A |
| T2 | 242 (19.87) | 662 (41.32) | 904 (32.06) | N/A |
| T3 | 724 (59.44) | 0 | 724 (25.67) | N/A |
| T4 | 103 (8.46) | 0 | 103 (3.65) | N/A |
| TX | 13 | 17 | 79 | N/A |
| N-stage | ||||
| N0 | 222 (70.03) | 302 (100.00) | 524 (84.65) | N/A |
| N1 | 95 (29.97) | 0 | 95 (15.35) | N/A |
| NX | 914 | 1317 | 2280 | N/A |
| M-stage | ||||
| M0 | 589 (68.25) | 655 (100.00) | 1244 (81.95) | N/A |
| M1 | 274 (31.75) | 0 | 274 (18.05) | N/A |
| MX | 368 | 964 | 1381 | N/A |
| Gleason (biopsy) | ||||
| ≤ 4 | 9 (0.83) | 98 (6.32) | 107 (4.06) | N/A |
| 5 | 43 (3.96) | 247 (15.93) | 290 (10.99) | N/A |
| 6 | 153 (14.08) | 832 (53.64) | 985 (37.34) | N/A |
| 7 | 414 (38.09) | 374 (24.11) | 788 (29.87) | N/A |
| 8 | 258 (23.74) | 0 | 258 (9.78) | N/A |
| 9 | 185 (17.02) | 0 | 185 (7.01) | N/A |
| 10 | 25 (2.30) | 0 | 25 | N/A |
| Missing | 144 | 68 | 261 | N/A |
43 patients can not be classifed as aggressive or localized cases because of missing phenotypes