Table 2.
Association of prostate cancer risk and 19 SNPs identified from previous genome-wide association studies
| Variable | Chr | Position* | Allele tests
|
Model | P# | Reference publications | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Allele
|
Allele frequency | OR (95% CI) | P* | ||||||||
| Ref | Risk | Cases | Controls | ||||||||
| rs721048 | 2p15 | 63,043,382 | G | A | 0.20 | 0.19 | 1.09 (0.98–1.22) | 0.11 | -- | -- | Gudmundsson |
| rs2660753 | 3p12 | 87,193,364 | C | T | 0.10 | 0.08 | 1.32 (1.13–1.54) | 3.4E-04 | addtive | 3.9E-04 | Eeles |
| rs9364554 | 6q25 | 160,804,075 | C | T | 0.33 | 0.31 | 1.12 (1.02–1.22) | 0.02 | addtive | 0.02 | Eeles |
| rs10486567 | 7p15 | 27,749,803 | T | C | 0.78 | 0.76 | 1.12 (1.01–1.24) | 0.03 | dominant | 5.3E-03 | Thomas |
| rs6465657 | 7q21 | 97,654,263 | T | C | 0.51 | 0.47 | 1.16 (1.06–1.26) | 6.7E-04 | addtive | 8.9E-04 | Eeles |
| rs16901979 | 8q24 (2) | 128,194,098 | C | A | 0.06 | 0.03 | 1.66 (1.34–2.07) | 3.1E-06 | addtive | 4.2E-06 | Gudmundsson |
| rs6983267 | 8q24 (3) | 128,482,487 | T | G | 0.56 | 0.51 | 1.22 (1.12–1.33) | 3.6E-06 | addtive | 3.7E-06 | Yeager, Zheng |
| rs1447295 | 8q24 (1) | 128,554,220 | C | A | 0.17 | 0.14 | 1.21 (1.08–1.36) | 1.6E-03 | dominant | 8.4E-04 | Amundadottir |
| rs1571801 | 9q33 | 121,506,927 | G | T | 0.31 | 0.28 | 1.15 (1.05–1.26) | 3.8E-03 | addtive | 4.1E-03 | Duggan |
| rs7920517 | 10q11 | 51,202,627 | A | G | 0.47 | 0.44 | 1.12 (1.03–1.22) | 9.2E-03 | addtive | 1.0E-02 | Eeles |
| rs10993994 | 10q11 | 51,219,502 | C | T | 0.43 | 0.39 | 1.15 (1.05–1.25) | 1.6E-03 | addtive | 1.7E-03 | Eeles, Thomas |
| rs4962416 | 10q26 | 126,686,862 | A | G | 0.24 | 0.23 | 1.07 (0.97–1.18) | 0.20 | -- | -- | Thomas |
| rs7931342 | 11q13 | 68,751,073 | T | G | 0.51 | 0.47 | 1.13 (1.04–1.24) | 4.0E-03 | addtive | 4.3E-03 | Eeles |
| rs10896449 | 11q13 | 68,751,243 | A | G | 0.49 | 0.46 | 1.14 (1.05–1.25) | 2.1E-03 | addtive | 2.3E-03 | Eeles, Thomas |
| rs4430796 | 17q12 | 33,172,153 | C | T | 0.61 | 0.56 | 1.24 (1.14–1.35) | 8.5E-07 | addtive | 6.7E-07 | Gudmundsson |
| rs1859962 | 17q24.3 | 66,620,348 | T | G | 0.54 | 0.50 | 1.17 (1.08–1.28) | 2.0E-04 | addtive | 2.2E-04 | Gudmundsson |
| rs2735839 | 19q13 | 56,056,435 | A | G | 0.88 | 0.88 | 1.03 (0.91–1.18) | 0.62 | -- | -- | Eeles |
| rs5945572 | Xp11 | 51,062,719 | C | T | 0.42 | 0.38 | 1.19 (1.05–1.35) | 5.0E-03 | -- | 5.0E-03 | Gudmundsson |
| rs5945619 | Xp11 | 51,074,708 | A | G | 0.42 | 0.38 | 1.20 (1.06–1.36) | 3.5E-03 | -- | 3.5E-03 | Eeles |
*
Build35
P* is based on the allelic test which assumed a multiplicative model
P# is based on Cochran-Armitag trend test for additve models and χ2 test for dominant models