Table 4.

Sensitivity and specificity for prostate cancer using cumulative effect of 12 risk factors (11 SNPs and risk family hisory)

11 SNPs &family history											psa
	all cases vs controls		agg cases vs controls		nonaggcases vs controls		age ≥ 65 yr		age < 65 yr		cutoff	Sensitivity	Specificity
	2899 cases and 1722 controls		1280 cases and 1722 controls		1668 cases and 1722 controls		1558 cases and 1017 controls		1341 cases and 705 controls
cutoff	sensitivity	specificity	sensitivity	specificity	sensitivity	specificity	sensitivity	specificity	sensitivity	specificity
1	1.000	0.001	0.999	0.001	1.000	0.001	1.000	0.000	0.999	0.001
2	0.998	0.003	0.996	0.003	1.000	0.003	0.999	0.003	0.997	0.004
3	0.997	0.007	0.994	0.007	0.999	0.007	0.998	0.007	0.994	0.007
4	0.989	0.020	0.986	0.020	0.991	0.020	0.990	0.020	0.985	0.023
5	0.976	0.048	0.972	0.048	0.978	0.048	0.974	0.044	0.968	0.074
6	0.944	0.105	0.937	0.105	0.948	0.105	0.944	0.098	0.908	0.150
7	0.865	0.208	0.857	0.208	0.869	0.208	0.865	0.206	0.817	0.292	1.1	0.834	0.389
8	0.741	0.363	0.714	0.363	0.762	0.363	0.730	0.361	0.671	0.477	1.6	0.67	0.587
9	0.581	0.552	0.559	0.552	0.600	0.552	0.573	0.554	0.477	0.674	2.1	0.526	0.725
10	0.403	0.738	0.384	0.738	0.419	0.738	0.388	0.752	0.304	0.817	2.6	0.405	0.811
											3.1	0.322	0.867
11	0.245	0.860	0.234	0.860	0.255	0.860	0.235	0.869	0.161	0.928	4.1	0.205	0.938
12	0.129	0.946	0.120	0.946	0.137	0.946	0.122	0.947	0.069	0.980
13	0.051	0.985	0.051	0.985	0.052	0.985	0.050	0.984	0.021	0.997	6.1	0.046	0.985
14	0.017	0.997	0.016	0.997	0.018	0.997	0.015	0.995	0.010	1.000	8.1	0.017	0.994
15	0.006	0.999	0.007	0.999	0.005	0.999	0.004	0.998	0.003	1.000	10.1	0.009	0.997
16	0.002	1.000	0.001	1.000	0.002	1.000	0.001	1.000	0.000	1.000
17	0.000	1.000	0.001	1.000	0.000	1.000	0.001	1.000	0.000	1.000