Table 1. Summary of Set1/MLL depletion.

S. cerevisiae	Human	C. elegans	H3K4me3	DCC
SET1	hSET1	set-2	reduced	WT
	MLL2/3	set-16	reduced	WT
SWD1/Cps50	RbBP5	F21H12.1	reduced	WT
SWD3/Cps30	WDR5	wdr-5.1	reduced	WT
		swd-3.2	reduced	WT
		swd-3.3	reduced	WT
SWD2/Cps35	WDR82	swd-2.1	reduced	WT
		swd-2.2	reduced	WT
	WDR83	F33G12.2	reduced	WT
SPP1/Cps40	CFP1	F52B11.1	reduced	WT
BRE2/Cps60	Ash2L	ash-2	reduced	WT
SDC1/Cps25	hDPY30	dpy-30	reduced	Diffuse
	HCF1/2	hcf-1	reduced	WT

The Set1/MLL homologs tested in this study are shown. Names of budding yeast and mammalian homologs are included for reference. Depletion of each subunit led to reduced H3K4me3 by IF or a combination of IF and western. Only dpy-30 depletion resulted in diffuse DCC localization. In all other Set1/MLL depletion animals, DCC localization appeared wild-type (WT).