Figure 2.

Comparative GO term enrichment analysis reveals functional homology between the Drosophila and human centrosome proteome. GO term enrichment in the category biological process level 3 was analyzed for all proteins classified as human centrosomal, centrosome candidate and centrosome novel⁵ using the DAVID bioinformatics tool and the whole human genome as the background. The Drosophila centrosome proteome was analyzed accordingly and statistically significantly enriched terms (p value < 0.01) were compared between the two datasets. Less informative terms not directly related to centrosome structure or function were merged and labeled with the term of the next higher level of the GO hierarchy (italic).