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. Author manuscript; available in PMC: 2012 Sep 16.
Published in final edited form as: Cell. 2011 Sep 1;146(6):904–917. doi: 10.1016/j.cell.2011.08.017

Figure 6. JQ1 induces cell cycle arrest and cellular senescence in MM cells.

Figure 6

(A-B) Flow cytometric evaluation of propidium iodide (PI) staining for cell cycle analysis (panel A) and detection of Annexin V-positive apoptotic cells (panel B) in JQ1-treated MM.1S cells (0 - 48hrs, 500 nM).

(C) Enrichment of senescence-associated genes among JQ1-suppressed genes in MM.1S cells.

(D) Induction of cellular senescence in JQ1 treated MM.1S cells (500 nM, 72 h), as detected by ß-galactosidase staining.