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(A) X-ray crystal structure of 4d (carbon = yellow) bound to human BRD4(1) (PDB ID: 3SVG). The conserved N140 residue is highlighted in green. Black dashed lines represent hydrogen bonds between 4d, structured water molecules (red spheres), and interacting residues (labeled). Image generated using PyMOL. (B) A schematic representation of the key interactions formed between 4d and human BRD4(1).
