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(A) X-ray crystal structure of 4b (carbon = yellow) bound to the bromodomain of human CREBBP (PDB ID: 3SVH). The conserved N1168 residue is highlighted in green. Black dashed lines represent hydrogen bonds among 4b, structured water molecules (red spheres), and interacting residues (labeled). Image generated using PyMOL. (B) Schematic representation of the key interactions formed between 4b and the bromodomain of human CREBBP.
