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. 2011 Aug 18;54(19):6761–6770. doi: 10.1021/jm200640v

Scheme 1. Synthesis of the 3′-Substituted 3,5-Dimethyl-4-phenylisoxazole Derivatives 3ac.

Scheme 1

Conditions: (a) R = H: Na2CO3, Pd(OAc)2, RuPhos, EtOH, 85 °C, 4 h, 85%. R = Ac: Na2CO3, Pd(OAc)2, RuPhos, EtOH, 85 °C, 13 h, 86%. R = OEt: Na2CO3, Pd(OAc)2, RuPhos, EtOH, 85 °C, 2 h, 87%.