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. Author manuscript; available in PMC: 2012 Sep 21.
Published in final edited form as: J Am Chem Soc. 2011 Aug 26;133(37):14704–14709. doi: 10.1021/ja204516p

Figure 1.

Figure 1

Design of highly efficient MRI contrast enhancement agents. (a) A crystal structure rendering of an MS2 coat protein dimer indicates the positions of the introduced cysteine residues (Cys 87) in red. (b) A rendering of the full 27 nm MS2 capsid shows the interior and exterior surfaces, with the 180 internal N87C positions highlighted in red. (c) The plan for increasing the overall relaxivity involved the use of more efficient cysteine modification chemistry and the rigidification of several rotable bonds (indicated in blue).