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. Author manuscript; available in PMC: 2012 Oct 1.
Published in final edited form as: Osteoarthritis Cartilage. 2011 Jul 23;19(10):1210–1218. doi: 10.1016/j.joca.2011.07.005

Figure 6. BCPs produce more GAG than hMSC or JC pellets when subjected to conditions that mimic the hypoxic, proinflammatory environment found in cartilage.

Figure 6

defects (*, p <.001). A DMMB assay revealed a significant advantage for BCP proteoglycan production relative to JC or hMSC pellets that were cultured with TNF-α (10 ng/mL) and IL1-β cytokines (10 ng/mL), and/or at 2% O2 for 21 days, N=10. Results were normalized to DNA content, N=10 (B), which showed no statistical differences between the cell types (hMSC, JC and BCP) within the conditions: TNFα/IL1β, Hypoxia or Hypoxia + TNFα/IL1β).