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. Author manuscript; available in PMC: 2012 Nov 1.
Published in final edited form as: Free Radic Biol Med. 2011 Aug 12;51(9):1749–1757. doi: 10.1016/j.freeradbiomed.2011.08.004

Figure 8. Reduced glucose and combined low glucose and insulin mediate de novo GSH synthesis, independently of ROS.

Figure 8

Panels A and B respectively show the effect of tempol, an ROS scavenger and BSO (GSH synthesis inhibitor) on hypoglycemia or combined hypoglycemia and insulin-induced endothelial GSH increases. The lack of an effect of tempol and the inhibitory effect of BSO are consistent with hypoglycemia (plus/minus insulin) mediating de novo GSH synthesis independent of a role for ROS. * p<0.001, 0.5 mM glucose versus 5 mM glucose (without or with insulin); # p<0.001, 0.5 mM glucose versus 0.5 mM glucose plus BSO (without or with insulin).