Table 3. Association between height, body shape at ages 5, 10 and 20 years and colorectal adenoma by subsite, stage and age at diagnosis.
| Adenoma subsite | Adenoma stage | Age at diagnosis c | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Proximal (1037 cases) |
Distal (1119 cases) |
Rectal (403 cases) |
Early a (1037 cases) |
Advanced b (680 cases) |
< 50 years (1098 cases) |
≥ 50 years (1229 cases) |
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| OR | (95% CI) | OR | (95% CI) | OR | (95% CI) | OR | (95% CI) | OR | (95% CI) | OR | (95% CI) | OR | (95% CI) | |
| Height (inches) | ||||||||||||||
| 50-<62 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |||||||
| 62-<65 | 0.98 | (0.77,1.25) | 1.24 | (0.95,1.64) | 0.94 | (0.64,1.38) | 1.10 | (0.86,1.41) | 1.13 | (0.81,1.57) | 1.14 | (0.86,1.52) | 1.02 | (0.80,1.29) |
| 65-<68 | 0.99 | (0.77,1.26) | 1.48 | (1.13,1.94) | 0.95 | (0.64,1.39) | 1.21 | (0.95,1.55) | 1.25 | (0.90,1.74) | 1.15 | (0.87,1.52) | 1.14 | (0.90,1.44) |
| ≥68 | 1.06 | (0.81,1.39) | 1.71 | (1.28,2.29) | 0.98 | (0.64,1.52) | 1.24 | (0.95,1.63) | 1.44 | (1.00,2.07) | 1.38 | (1.01,1.88) | 1.20 | (0.93,1.56) |
| ptrend | 0.47 | <0.0001 | 0.74 | 0.09 | 0.02 | 0.04 | 0.05 | |||||||
| Pictogram at age 5 years | ||||||||||||||
| 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |||||||
| 2 | 1.07 | (0.90,1.28) | 1.06 | (0.89,1.26) | 1.08 | (0.82,1.43) | 1.18 | (0.99,1.39) | 0.94 | (0.76,1.18) | 0.94 | (0.77,1.14) | 1.17 | (0.99,1.38) |
| 3 | 1.18 | (0.99,1.42) | 1.11 | (0.93,1.34) | 1.14 | (0.85,1.54) | 1.29 | (1.08,1.53) | 0.99 | (0.79,1.26) | 1.12 | (0.92,1.37) | 1.18 | (0.99,1.40) |
| 4 | 0.96 | (0.76,1.20) | 1.19 | (0.96,1.47) | 1.02 | (0.71,1.47) | 0.95 | (0.76,1.18) | 1.06 | (0.81,1.40) | 0.93 | (0.72,1.19) | 1.11 | (0.90,1.37) |
| ≥5 | 1.12 | (0.85,1.46) | 1.40 | (1.09,1.79) | 1.12 | (0.73,1.72) | 1.23 | (0.95,1.58) | 1.29 | (0.94,1.78) | 1.20 | (0.89,1.61) | 1.40 | (1.11,1.77) |
| ptrend | 0.43 | 0.01 | 0.57 | 0.35 | 0.14 | 0.27 | 0.01 | |||||||
| Pictogram at age 10 years | ||||||||||||||
| 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |||||||
| 2 | 1.08 | (0.90,1.31) | 1.05 | (0.87,1.27) | 0.90 | (0.67,1.21) | 1.08 | (0.90,1.30) | 0.95 | (0.74,1.21) | 0.94 | (0.76,1.17) | 1.06 | (0.89,1.27) |
| 3 | 1.10 | (0.90,1.35) | 1.07 | (0.88,1.31) | 0.93 | (0.68,1.28) | 1.14 | (0.94,1.38) | 0.98 | (0.76,1.26) | 1.06 | (0.85,1.32) | 1.06 | (0.88,1.28) |
| 4 | 1.05 | (0.84,1.30) | 1.15 | (0.93,1.42) | 0.97 | (0.69,1.37) | 0.95 | (0.77,1.18) | 1.13 | (0.86,1.49) | 0.95 | (0.75,1.22) | 1.13 | (0.92,1.38) |
| ≥5 | 1.12 | (0.89,1.41) | 1.23 | (0.98,1.53) | 0.82 | (0.56,1.19) | 1.09 | (0.87,1.36) | 1.18 | (0.89,1.57) | 1.07 | (0.83,1.38) | 1.23 | (1.00,1.52) |
| ptrend | 0.45 | 0.04 | 0.53 | 0.93 | 0.12 | 0.61 | 0.03 | |||||||
small/tubular
large or tubulovillous or villous or highgrade dysplasia
for controls: age at most recent endoscopy
Models for pictogram at age 5 years or 10 years multivariate adjusted for age, family history of colorectal cancer, time period of endoscopy, number of reported endoscopies during the study period (one endoscopy vs. ≥2 endoscopies), reason for most recent endoscopy, height (continuous), packyears of smoking (0, 0-10,>10-20, >20-40,>40), current physical activity (quintiles), aspirin use (never, past, current 1 day/week, 2-3 days/week, 4-5 days/week, ≥6 days/week), current cumulative average alcohol intake (quintiles), current cumulative average dietary intake of red meat, processed meat, folate and calcium (quintiles)
Models for height adjusted for all variables mentioned above excluding height, but including current cumulative updated average BMI (continuous)