Table 1.
Treatment plan showing groups of Sprague-Dawley rats treated with unmodified and nanoparticle forms of chemopreventive agents aspirin (ASP), folic acid (FA) and calcium (Ca) at various doses.
| Set | Group (n=6) | Treatment Plan | Dose (mg/kg) |
|---|---|---|---|
| S 1 (unmodified combination) | G1 | Saline (control) | 0 |
| G2 | AOM (control) | 0 | |
| G3 | ASP + FA + Ca | 400 + 32 + 650 | |
| G4 | ASP + FA + Ca | 133 + 11 + 216 | |
| G5 | ASP + FA + Ca | 40 + 3.2 + 65 | |
| G6 | ASP + FA + Ca | 13 + 1.1 + 22 | |
| G7 | ASP + FA + Ca | 4 + 0.32 + 6.5 | |
| S 2 (unmodified and modified combination) | G8 | Saline (control) | 0 |
| G9 | AOM (control) | 0 | |
| G10 | ASP + FA + Ca | 133 + 11 + 216 | |
| G11 | ASP + FA + Ca | 80 + 6.4 + 130 | |
| G12 | ASP + FA + Ca | 40 + 3.2 + 65 | |
| G13 | ASP (NP) + FA (NP) + Ca | 133 + 11 + 216 | |
| G14 | ASP (NP) + FA (NP) + Ca | 80 + 6.4 + 130 | |
| G15 | ASP (NP) + FA (NP) + Ca | 40 + 3.2 + 65 | |
| S 3 (modified combination) | G16 | Saline (control) | 0 |
| G17 | AOM (control) | 0 | |
| G18 | ASP (NP) | 40 | |
| G19 | FA (NP) | 3.2 | |
| G20 | Ca | 65 | |
| G21 | ASP (NP) + FA (NP) + Ca | 40 + 3.2 + 65 |