Table 5.
Association of meat-derived mutagen exposure and risk of polyps, the Tennessee Colorectal Polyp Study (TCPS), 2003–2010.
| Exposure amount |
Controls (N=3,764) |
Any polyps (N=2,543) |
Polyp groups |
||||
|---|---|---|---|---|---|---|---|
| Adenomas (N= 1,881) |
HPP only (N=662) |
||||||
| n | n | OR (95% CI)1 | n | OR (95% CI)1 | n | OR (95% CI)1 | |
| MeIQx (ng/day) | |||||||
| ≤12.2 | 1041 | 499 | 1.0 (reference) | 370 | 1.0 (reference) | 129 | 1.0 (reference) |
| 12.3–32.9 | 906 | 552 | 1.2(1.0–1.4) | 410 | 1.2(1.0–1.4) | 142 | 1.2(0.9–1.5) |
| 33.0–70.0 | 909 | 645 | 1.3(1.1–1.5) | 468 | 1.3 (1.1–1.5) | 177 | 1.3(1.0–1.7) |
| ≥70.1 | 908 | 847 | 1.4(1.2–1.6) | 633 | 1.4(1.2–1.7) | 214 | 1.3 (1.0–1.7) |
| P-trend | <0.001 | <0.001 | 0.022 | ||||
| PhIP (ng/day) | |||||||
| ≤73.3 | 1038 | 571 | 1.0 (reference) | 426 | 1.0 (reference) | 145 | 1.0 (reference) |
| 79.4–169.3 | 908 | 554 | 1.1 (0.9–1.3) | 412 | 1.1 (0.9–1.3) | 142 | 1.1 (0.8–1.4) |
| 169.4–339.3 | 909 | 691 | 1.3 (1.1–1.5) | 502 | 1.3 (1.1–1.6) | 189 | 1.3 (1.0–1.7) |
| ≥339.4 | 909 | 727 | 1.3 (1.1–1.5) | 541 | 1.3 (1.1–1.5) | 186 | 1.2(0.9–1.6) |
| P-trend | <0.001 | 0.001 | 0.053 | ||||
| DiMeIQx (ng/day) | |||||||
| ≤0.82 | 1039 | 577 | 1.0 (reference) | 433 | 1.0 (reference) | 144 | 1.0 (reference) |
| 0.83–2.74 | 909 | 560 | 1.1 (0.9–1.3) | 413 | 1.1 (0.9–1.3) | 147 | 1.0(0.8–1.3) |
| 2.75–5.95 | 908 | 597 | 1.1 (0.9–1.3) | 432 | 1.1 (0.9–1.3) | 165 | 1.1 (0.9–1.5) |
| ≥5.96 | 908 | 809 | 1.3 (1.1–1.5) | 603 | 1.3 (1.1–1.6) | 206 | 1.3 (1.0–1.6) |
| P-trend | <0.001 | 0.001 | 0.034 | ||||
| Benzo[α]pyrene (ng/day) | |||||||
| ≤8.93 | 1038 | 551 | 1.0 (reference) | 411 | 1.0 (reference) | 140 | 1.0 (reference) |
| 8.94–31.9 | 909 | 633 | 1.1 (1.0–1.3) | 462 | 1.1 (0.9–1.3) | 171 | 1.2(0.9–1.6) |
| 32.0–79.8 | 909 | 645 | 1.2(1.0–1.4) | 481 | 1.2(1.0–1.4) | 164 | 1.2(0.9–1.5) |
| ≥79.9 | 908 | 714 | 1.2(1.0–1.4) | 527 | 1.2(1.0–1.5) | 187 | 1.2(0.9–1.5) |
| P-trend | 0.026 | 0.027 | 0.434 | ||||
| Mutageneity index | |||||||
| ≤2,556 | 1038 | 520 | 1.0 (reference) | 404 | 1.0 (reference) | 125 | 1.0 (reference) |
| 2,557–5,851 | 908 | 518 | 1.1 (0.9–1.2) | 414 | 1.2(1.0–1.4) | 168 | 1.5 (1.1–1.9) |
| 5,852- | 909 | 668 | 1.4(1.2–1.6) | 495 | 1.4(1.2–1.6) | 167 | 1.4(1.1–1.8) |
| ≥111,021 | 909 | 837 | 1.3 (1.1–1.6) | 568 | 1.3 (1.1–1.6) | 202 | 1.5 (1.2–1.9) |
| P-trend | <0.001 | <0.001 | 0.008 | ||||
HPP: hyperplastic polyp.
1
Adjusted for age, sex, race, study sites, educational attainment, indications for colonoscopy, smoking, alcohol consumption, BMI, physical activity, regular NSAIDs use, total energy intake, and recruitment before or after colonoscopy.