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. Author manuscript; available in PMC: 2012 Nov 1.

Published in final edited form as: Acad Radiol. 2011 Nov;18(11):1341–1348. doi: 10.1016/j.acra.2011.06.013

Effect of delivery vehicle on the concentration of doxorubicin in plasma. Vehicles include: 12 mg UCA , 12 mg nanoparticles , a combination of 6 mg nanoparticles and 6 mg UCA or free doxorubicin . After 5 minutes plasma drug concentrations were significantly greater in rats treated with free doxorubicin compared to all other treatments (p<0.0470) and concentrations were significantly greater in rats treated with nanoparticles compared to UCAs (p=0.0052). n=5

Inline graphic — Effect of delivery vehicle on the concentration of doxorubicin in plasma. Vehicles include: 12 mg UCA , 12 mg nanoparticles , a combination of 6 mg nanoparticles and 6 mg UCA or free doxorubicin . After 5 minutes plasma drug concentrations were significantly greater in rats treated with free doxorubicin compared to all other treatments (p<0.0470) and concentrations were significantly greater in rats treated with nanoparticles compared to UCAs (p=0.0052). n=5