Table 1.

Mean Frequency of SIV Envelope Mutations in Plasma and CSF by Variable Region from Morphine-dependent and Control Macaques

Group	Monkey Number	Sampling Time (week)	Mean frequency of mutations by variable regiona
			Plasma				CSF
Morphine			No. of clones	V3	V4	V5	No. of clones	V3	V4	V5
Rapid	1/04L	12	9	0.333	1.889	0.667	7	0.143	0.571	0.429
		18	7	0.286	1.857	0.286	9	0.111	1.110	0.444
	1/28Q	12	7	0	0.429	0.857	7	0.142	0.714	1.143
		18	6	0	0.500	0.167	5	0	0.400	0.800
	1/42N	12	7	0.143	1.000	0.429	8	0	1.250	0.125
		18	8	0	0.625	0.125	5	0.200	0.200	0
Normal	1/02N	12	10	0.200	0.400	0.100	7	0	0.571	0.857
		18	6	0.500	0.167	0	9	0	0.556	0.556
	1/52N	12	3	0	0.333	0.667	6	0	0.375	0
		18	9	0	0.222	0	9	0	1.000	0.111
	1/56L	12	8	0.125	0	0	8	0	0.250	0.125
		18	8	0.125	0	0.125	9	0	0.333	0.333
Control
	2/02P	12	8	0	0.250	0.375	6	0.167	0	0
		18	7	0.571	0.143	0.286	7	0.286	0	0
	2/31P	12	5	0	0	0.400	7	0.143	0	0.143
		18	5	0	0.200	0	2	0	0	0
	2/AC42	12	5	0.250	0	0	7	0	0	0.143
		18	7	0.143	0	0.286	5	0	0	0

^aMean frequency of mutation by variable region was region in a monkey at a given time point divided