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. Author manuscript; available in PMC: 2012 Oct 4.
Published in final edited form as: Biochemistry. 2011 Sep 8;50(39):8463–8477. doi: 10.1021/bi201007t

Figure 7. Exchange rate of DNA imino protons at three concentrations of glycine catalyst.

Figure 7

In each histogram, the kex values for base imino protons in the parent (blue) and 8oxoG lesion duplexes (red) are shown in pairs. (A) 5 mM total glycine (12.5 µM active glycine base catalyst) illustrating the exchange rate of one of the terminal peaks and the 8oxoG N7 imino proton, both of which are quite accessible to solution and exchange much more quickly than the internal imino protons. (B) 5 mM total glycine (12.5 µM base) with the y-axis adjusted to illustrate the exchange rates of the internal imino protons. (C) 100 mM total glycine (250 µM base). (D) 1000 mM total glycine (2.5 mM base).