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. Author manuscript; available in PMC: 2012 Oct 4.
Published in final edited form as: Biochemistry. 2011 Sep 8;50(39):8463–8477. doi: 10.1021/bi201007t

Table 2.

Base Pair Exchange and Opening Parameters†

αKop × 106 kint × 10−6, M−1 s−1
duplex 1–2 duplex 1oxo-2 duplex 1–2 duplex 1oxo-2
G29/G14 35 ± 2 22 ± 3 0.068 ± 0.005 0.15 ± 0.03
G8 or oxoG8 1.8 ± 0.4 1.6 ± 0.6 0.87 ± 0.2 1.7 ± 0.6
G21 1.7 ± 0.5 1.1 ± 0.4 0.81 ± 0.2 1.6 ± 0.6
G6 2.2 ± 0.5 1.3 ± 0.7 1.0 ± 0.2 2.1 ± 1.1
G26 2.4 ± 0.5 2.8 ± 0.7 0.81 ± 0.2 0.81 ± 0.2
G12 0.77 ± 0.3 0.97 ± 0.4 2.4 ± 0.9 2.1 ± 0.8
T13 4.8 ± 0.3 3.1 ± 0.7 0.38 ± 0.02 0.70 ± 0.2
T4 0.84 ± 0.2 1.0 ± 0.4 2.1 ± 0.5 1.9 ± 0.8
†

αKop= the apparent equilibrium constant for base pair opening; kint = the intrinsic rate of imino proton exchange, M−1 s−1.