Table 1.
Frequency of G6PD genotypes in malaria patients from 17 centres in six African countries
| Country | Centre | Male N | A- | A | B | Female N | A-A- | AA- | BA- | AA | BB | BA | HW* p |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BF | Bobo-Dioulasso | 1 | 0 | 1 (100) | 0 | 4 | 0 | 0 | 2 (50.0) | 0 | 1 (25.0) | 1 (25.0) | NC |
| Ouagadougou | 174 | 27 (15.5) | 48 (27.6) | 99 (56.9) | 178 | 6 (3.4) | 15 (8.4) | 33 (18.5) | 18 (10.1) | 54 (30.3) | 52 (29.2) | 0.742 | |
| Total | 175 | 27 (15.4) | 49 (28.0) | 99 (56.6) | 182 | 6 (3.3) | 15 (8.2) | 35 (19.2) | 18 (9.9) | 55 (30.2) | 53 (29.1) | 0.771 | |
| Ghana | Kintampo | 92 | 16 (17.4) | 52 (56.5) | 24 (26.1) | 87 | 8 (9.2) | 10 (11.5) | 21 (24.1) | 9 (10.3) | 22 (25.3) | 17 (19.5) | 0.003 |
| Kumasi | 19 | 2 (10.5) | 4 (21.1) | 13 (68.4) | 38 | 1 (2.6) | 1 (2.6) | 5 (13.2) | 6 (15.8) | 13 (34.2) | 12 (31.6) | 0.019 | |
| Total | 111 | 18 (16.2) | 28 (25.2) | 65 (58.6) | 125 | 9 (7.2) | 11 (8.8) | 26 (20.8) | 15 (12.0) | 35 (28.0) | 29 (23.2) | 0.001 | |
| Kenya | Eldoret | 77 | 15 (19.5) | 22 (28.6) | 40 (51.9) | 72 | 2 (2.8) | 2 (2.8) | 10 (13.9) | 1 (1.4) | 42 (58.3) | 15 (20.8) | < 0.001 |
| Kilifi | 41 | 8 (19.5) | 10 (24.4) | 23 (56.1) | 33 | 2 (6.1) | 3 (9.1) | 8 (24.2) | 1 (3.0) | 10 (30.3) | 9 (27.3) | 0.961 | |
| Pingilikani | 39 | 5 (12.8) | 7 (17.9) | 27 (69.2) | 31 | 1 (3.2) | 7 (22.6) | 5 (16.1) | 1 (3.2) | 11 (35.5) | 6 (19.4) | < 0.001 | |
| Total | 157 | 28 (17.8) | 39 (24.8) | 90 (57.3) | 136 | 5 (3.7) | 12 (8.8) | 23 (16.9) | 3 (2.2) | 63 (46.3) | 30 (22.1) | 0.016 | |
| Mali | Doneguebougou | 114 | 10 (8.8) | 41 (36.0) | 63 (55.3) | 102 | 2 (2.0) | 4 (3.9) | 20 (19.6) | 14 (13.7) | 39 (38.2) | 23 (22.5) | < 0.001 |
| Banambani | 48 | 7 (14.6) | 13 (27.1) | 28 (58.3) | 44 | 1 (2.3) | 1 (2.3) | 7 (15.9) | 2 (4.5) | 23 (52.3) | 10 (22.7) | 0.176 | |
| Total | 162 | 17 (10.5) | 54 (33.3) | 91 (56.2) | 146 | 3 (2.1) | 5 (3.4) | 27 (18.5) | 16 (11.0) | 62 (42.5) | 33 (22.6) | < 0.001 | |
| Nigeria | Calabar | 76 | 11 (14.5) | 11 (14.5) | 54 (71.1) | 69 | 0 | 7 (10.1) | 13 (18.8) | 5 (7.2) | 33 (47.8) | 11 (15.9) | 0.005 |
| Enugu | 121 | 17 (14.1) | 32 (26.4) | 72 (59.5) | 98 | 5 (5.1) | 11 (11.2) | 23 (23.5) | 1 (1.0) | 41 (41.8) | 17 (17.3) | 0.001 | |
| Ibadan | 26 | 2 (7.7) | 2 (7.7) | 22 (84.6) | 30 | 0 | 3 (10.0) | 4 (13.3) | 3 (10.0) | 15 (50.0) | 5 (16.7) | < 0.001 | |
| Ile Ife | 49 | 7 (14.3) | 14 (28.6) | 28 (57.1) | 57 | 5 (8.8) | 4 (7.0) | 14 (24.6) | 4 (7.0) | 20 (35.1) | 10 (17.5) | 0.002 | |
| Jos | 11 | 0 | 4 (36.4) | 7 (63.6) | 10 | 0 | 2 (20.0) | 1 (10.0) | 3 (30.0) | 2 (20.0) | 2 (20.0) | NC | |
| Total | 283 | 37 (13.1) | 63 (22.3) | 183 (64.7) | 264 | 10 (3.8) | 27 (10.2) | 55 (20.8) | 16 (6.1) | 111 (42.0) | 45 (17.0) | < 0.001 | |
| Tanzania | Bagamoyo | 19 | 4 (21.1) | 4 (21.1) | 11 (57.9) | 23 | 0 | 0 | 0 | 5 (21.7) | 13 (56.5) | 5 (21.7) | < 0.001 |
| Kiwangwa | 111 | 16 (14.4) | 18 (16.2) | 77 (69.4) | 151 | 4 (2.6) | 11 (7.3) | 26 (17.2) | 3 (2.0) | 60 (39.7) | 47 (31.1) | 0.063 | |
| Total | 130 | 20 (15.4) | 22 (16.9) | 88 (67.7) | 174 | 4 (2.3) | 11 (6.3) | 26 (14.9) | 8 (4.6) | 73 (42.0) | 52 (29.9) | 0.094 | |
| Total | 1018 | 147 (14.4) | 283 (27.8) | 588 (57.8) | 1027 | 37 (3.6) | 81 (7.9) | 192 (18.7) | 76 (7.4) | 399 (38.8) | 242 (23.5) | < 0.001 |
Data shown as n (%) BF, Burkina Faso; NC, not calculated. G6PD genotype: male hemizygous = A-; male normal = A or B; female homozygous = A-/A-; female heterozygous = A/A- or B/A-; and female normal = A/A, B/B or B/A
*p values < 0.05 indicate significant differences from predicted G6PD gene frequencies in females based on male gene frequencies for A-, A and B alleles using the Hardy-Weinberg equation (Chi-squared)