Table 4.
Baseline demographic and clinical data by G6PD genotype
| Characteristic* | Male hemizygous (n = 147) |
Male normal (n = 871) |
Female homozygous (n = 37) |
Female heterozygous (n = 273) |
Female normal (n = 717) |
All patients (n = 2045) |
|---|---|---|---|---|---|---|
| Age, years [range] | 5.8 (8.0) [1-70] | 5.1 (5.5) [1-59] | 7.9 (10.0) [1-42] | 5.6 (7.8) [1-72] | 5.6 (6.5) [1-72] | 5.44 (6.5) [1-72] |
| 1- < 5, n (%) | 87 (59) | 511 (59) | 21 (57) | 169 (62) | 412 (57) | 1200 (59) |
| 5- < 15, n (%) | 52 (35) | 331 (38) | 10 (27) | 90 (33) | 277 (39) | 760 (37) |
| ≥ 15, n (%) | 8 (5) | 29 (3) | 6 (16) | 14 (5) | 28 (4) | 85 (4) |
| Weight, kg, mean | 18.8 (11.7) | 17.9 (10.5) | 23.1 (21.9) | 18.0 (12.2) | 18.3 (11.0) | 18.2 (11.3) |
| Parasitaemia, μL-1, geometric mean [range] | 25990 [1484-705600] |
26331 [216-323361] |
18602 [1026-211546] |
22498 [0-303400] |
27213 [0-389415] |
25895 [0-705600] |
| Temperature, °C | 37.8 (1.0) | 37.9 (1.0) | 37.9 (1.0) | 37.8 (1.0) | 37.9 (1.0) | 37.9 (1.0) |
| Fever, n (%) | 81 (55.1) | 552 (63.4) | 24 (65.0) | 165 (60.0) | 459 (64.0) | 1281 (62.6) |
| Haemoglobin, g/L* | 100.3 (18.3) | 101.1 (16.8) | 99.7 (19.2) | 100.6 (14.2) | 102.7 (15.6) | 101.5 (16.2) |
| 1 to < 5 years | 93.2 (15.2) | 95.6 (14.6) | 91.0 (16.5) | 96.1 (12.6) | 97.3 (14.6) | 96.0 (14.5) |
| 5 to < 15 years | 107.2 (15.2) | 106.6 (14.8) | 104.4 (12.5) | 105.8 (13.2) | 108.9 (13.9) | 107.3 (14.3) |
| ≥ 15 years | 132.5 (16.5) | 135.7 (12.2) | 122.5 (17.5) | 119.9 (11.9) | 120.5 (9.8) | 126.9 (14.0) |
| Haematocrit, L | 0.30 (0.05) | 0.30 (0.05) | 0.31 (0.05) | 0.31 (0.04) | 0.31 (0.04) | 0.31 (0.05) |
| RBC count x1012/L | 4.0 (0.7) | 4.2 (0.6) | 4.0 (0.6) | 4.0 (0.5) | 4.1 (0.6) | 4.1 (0.62) |
| Platelet count x109/L | 191.4 (86.5) | 196.7 (111.6) | 206.1 (125.2) | 186.9 (96.4) | 198.1 (128.0) | 195.7 (114.5) |
| WBC count x109/L | 9.6 (4.3) | 9.5 (4.1) | 8.5 (4.2) | 9.5 (3.9) | 9.4 (4.0) | 9.5 (4.0) |
| Treatment n (%) | ||||||
| CDA 005 | 64 (43.5) | 324 (37.2) | 16 (43.2) | 123 (45.1) | 273 (38.1) | 800 (39.1) |
| CDA 006 | 38 (25.9) | 250 (28.7) | 6 (16.2) | 70 (25.6) | 198 (27.6) | 562 (27.5) |
| AL | 30 (20.4) | 185 (21.2) | 6 (16.2) | 43 (15.8) | 137 (19.1) | 401 (19.6) |
| CPG-DDS | 15 (10.2) | 112 (12.9) | 9 (24.3) | 37 (13.6) | 109 (15.2) | 282 (13.8) |
All values are mean (SD) [range] unless otherwise indicated. CDA, chlorproguanil-dapsone-artesunate; AL, artemether-lumefantrine; CPG-DDS, chlorproguanil-dapsone; RBC, red blood cell; WBC, white blood cell. G6PD genotype: male hemizygous = A-; male normal = A or B; female homozygous = A-/A-; female heterozygous = A/A- or B/A-; and female normal = A/A, B/B or B/A
*There were 23 patients with baseline haemoglobin of < 70 g/L (range 45-69 g/L, mean 65 g/L). This occurred because at some sites screening haemoglobin level was determined using a rapid test (Haemacue, Downfield, UK), with subsequent checking using a coulter counter the results of which are reported here.