Figure 1.

(a) Effective diffusion coefficients, D_eff, as a function of their experimental hydrodynamic radius, R_H. Diffusion coefficients in PBS solution were measured at T = 26°C and scaled to 37°C according to the Stokes–Einstein equation. Diffusion coefficients were measured in DC (filled symbols and dotted lines) and CW (open symbols and continuous line) tumors. (b) Interstitial diffusion coefficients in tumors (D_int = τD_eff) as a function of hydrodynamic radius, R_H, using the experimentally obtained value τ_g = 1.19. The diffusion coefficients in solution (D₀) are pictured (▴) to illustrate the ECM influence on retardation.