Figure 7. Dynamic isotopic intracellular metabolite measurements in aerobic growing cells during metabolism of U-¹³C glucose.

Schematic illustration of glycolysis and the TCA cycle and graphs of isotopomer distribution during metabolism of U-¹³C glucose. H₃₇Rv was grown under aerobic conditions in Dubos medium where glucose was replaced with U-¹³C glucose followed by metabolomics analyses over time. Under aerobic conditions the isotopomer distribution supports forward flux through the oxidative TCA.