Table 7.
Putative P. larvae antibiotic resistance proteins based on matches to conserved domains
| Protein (E-value) | Domain, functional information from CDD |
|---|---|
|
EFX43850 (3E-37), EFX47127 (3E-26), EFX43889 (2E-44), |
ABC_BcrA_bacitracin_resist [cd03268]: The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance; bacitracin is an antibiotic produced by B. licheniformis and B. subtilis with potent antibiotic activity against gram-positive bacteria |
| EFX46602 (1E-57), | |
| EFX44842 (2E-50), | |
| EFX46272 (4E-41), | |
| EFX45233 (9E-52) | |
| EFX46614 (4E-25), | ABC_DR_subfamily_A [cd03230]: This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity |
| EFX44699 (4E-16), | |
| EFX45065 (1E-50) | ABC_DrrA [cd03265]: DrrA is the ATP-binding protein component of a bacterial exporter complex that confers resistance to the antibiotics daunorubicin and doxorubicin |
| EFX46465 (1E-55), | ABC_drug_resistance_like [cd03264]: ABC-type multidrug transport system, ATPase component |
| EFX45467 (3E-61), | |
| EFX45475 (2E-48*) | |
| EFX43892 (1E-42), | ABC_putative_ATPase [cd03269]: This subfamily is involved in drug resistance, nodulation, lipid transport, and bacteriocin and lantibiotic immunity |
| EFX46872 (1E-35), | |
| EFX47099 (4E-20*), | |
| EFX45045 (1E-71*) | |
| EFX46236 (3E-6*) | ABCC_MRP_Like [cd03228]: The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export; they belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. |
| EFX44443 (3E-26) | ACR_tran [pfam00873]: AcrB/AcrD/AcrF family. Members of this family are integral membrane proteins. Some are involved in drug resistance |
| EFX44702 (4E-33), | CcmA [COG1131]: ABC-type multidrug transport system, ATPase component |
| EFX46006 (5E-34), | |
| EFX44595 (4E-16), | |
| EFX43880 (8E-54), | |
| EFX47052 (7E-40), | |
| PL1_2983 (1E-33), | |
| EFX46146 (6E-40), | |
| EFX45253 (3E-22), | |
| EFX45810 (9E-18), | |
| EFX45945 (1E-18), | |
| EFX47082 (9E-21*), | |
| EFX44360 (3E-15*), | |
| EFX46805 (6E-30*), | |
| EFX45180 (5E-27*) | |
| EFX43881 (3E-4*) | COG0842 [COG0842]: ABC-type multidrug transport system, permease component |
| EFX44713 (1E-52) | COG2409 [COG2409]: Predicted drug exporters of the RND superfamily |
| EFX47096 (4E-18) | COG4152 [COG4152]: ABC-type uncharacterized transport system, ATPase component |
| EFX46793 (6E-34) | COG4586 [COG4586]: ABC-type uncharacterized transport system, ATPase component |
| EFX46612 (2E-58), | drrA [TIGR01188]: daunorubicin resistance ABC transporter ATP-binding subunit |
| EFX43786 (8E-63), | |
| EFX45226 (4E-54), | |
| EFX44634 (3E-36*) | |
| EFX43785 (4E-5) | drrB [TIGR01247]: daunorubicin resistance ABC transporter membrane protein; the protein associated with effux of the drug, daunorubicin |
|
EFX44398 (8E-11), EFX47139 (1E-59) |
efflux_Bcr_CflA [TIGR00710]: drug resistance transporter, Bcr/CflA subfamily |
| EFX46169 (4E-40), | efflux_EmrB [TIGR00711]: drug resistance transporter, EmrB/QacA subfamily |
| EFX44387 (7E-37), | |
| EFX44446 (8E-09), | |
| EFX46307(5E-24), | |
| EFX46126 (1E-53), | |
| EFX44956 (3E-9*) | |
| EFX46708 (3E-14) | emrE [PRK09541]: multidrug efflux protein |
| EFX44177 (2E-4*) | Glyoxalase [pfam00903]: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily |
| EFX45543 (4E-10), | HTH_MARR [smart00347]: helix_turn_helix multiple antibiotic resistance protein |
| EFX43861 (8E-11), | |
| EFX46148 (6E-10), | |
| EFX46170 (4E-12), | |
| EFX44712 (3E-12), | |
| EFX45783 (3E-6*), | |
| EFX46306 (1E-8*), | |
| EFX46227 (3E-4*), | |
| EFX44716 (5E-9*) | |
| EFX45439 (2E-48) | Lant_dehyd_C [pfam04738]: Lantibiotic dehydratase, C terminus |
| EFX45438 (3E-31) | LanC [cd04793]: LanC is the cyclase enzyme of the lanthionine synthetase. Lanthinoine is a lantibiotic, a unique class of peptide antibiotics |
|
EFX46802 (4E-77*), EFX46803 (4E-12*) |
LcnDR2 [COG4403]: Lantibiotic modifying enzyme |
| EFX45784 (1E-84), | MdlB [COG1132]: ABC-type multidrug transport system; ATPase and permease components |
| EFX45333 (6E-107), | |
| EFX44415 (7E-47*), | |
| EFX44416 (5E-44*), | |
| EFX45434 (1E-26*) | |
| EFX45348 (3E-36) | NorM [COG0534]: Na+-driven multidrug efflux pump |
| EFX45532 (1E-114) | PRK01766 [PRK01766]: multidrug efflux protein |
| EFX46249 (6E-16) | PRK03545 [PRK03545]: sugar efflux transporter |
|
EFX46262 (2E-15), EFX44433 (8E-82) |
PRK09874 [PRK09874]: drug efflux system protein MdtG |
| EFX45329 (5E-21) | PRK10054 [PRK10054]: putative MFS-type transporter YdeE |
| EFX47111 (5E-4*) | PRK10504 [PRK10504]: multidrug efflux system protein MdtE |
| EFX45115 (3E-58*) | PRK10522 [PRK10522]: multidrug transporter membrane component/ATP-binding component |
| EFX47080 (1E-129) | PRK10789 [PRK10789]: putative multidrug transporter membrane\ATP-binding components |
| EFX47079 (5E-98) | PRK10790 [PRK10790]: putative multidrug transporter membrane\ATP-binding components |
| EFX45606 (2E-13) | PRK11102 [PRK11102]: bicyclomycin/multidrug efflux system |
|
EFX46841 (4E-19), EFX46842 (3E-13) |
PRK11431 [PRK11431]: quaternary ammonium compound-resistance protein SugE |
| EFX43805 (8E-7*) | PRK11646 [PRK11646]: multidrug resistance protein MdtH |
| EFX47100 (4E-6) | RND_mfp [TIGR01730]: RND family efflux transporter, MFP subunit |
*the listed match is not the one with the lowest E-value; it is displayed because it is the most informative