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. 2011 Oct 6;6(10):e24832. doi: 10.1371/journal.pone.0024832

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10⁸ pfu dose, Day 11: Marked lymphoid hyperplasia with large numbers of secondary follicles containing well developed germinal centers (*), H&E 5X; mag bar = 100 um. Poxviral immunohistochemistry (right) is negative, anti-vaccinia IHC; 5X; mag bar = 100 um. 10⁹ pfu dose, premature death group, Day 2: Follicular depletion and lymphocytolysis with abundant apoptotic debris, H&E 20X; mag bar = 50 um. Poxviral IHC staining (brown) is localized to the mantle zone and scattered individual cells within the paracortex and sinuses, anti-vaccinia IHC; 20X; mag bar = 50 um.