Fig. 2.

Model for direct reprogramming and initiation of process in unc-3 mutants. (A) Alternative models of cellular reprogramming: (1) the initial (A) and final (B) cell identities overlap during transition; and (2) an intermediate cell state exists that lacks both identities. (B,C) Expression of a Y and P12.pa marker (egl-26 transgene, B) and a Y and U cell marker (egl-5 transgene, C) indicate that a normal Y cell is present in e151 mutants at the L1 larval stage, but is no longer part of the rectum at the L3 larval stage and is replaced by P12.pa. Anterior is to the left and ventral to the bottom. (D,E) Schematics of the egl-5 and egl-26 transgene expression during the L1 to L3 larval stages in WT and unc-3 mutants.