Table 1.
Results from analysis of CSF from individuals with recent onset schizophrenia, chronic schizophrenia, individuals with noninflammatory neurological disorder and individuals with no history of psychiatric disease
| Patient group | n | No. with retrovirus sequence
|
|||
|---|---|---|---|---|---|
| HERV-W | ERV9 | ERV-FRD | Total | ||
| Recent onset | 35 | 7 | 2 | 1 | 10 (28.6%)* |
| Chronic | 20 | 1 | ND | ND | 1 (5%) |
| Neurological | 22 | ND | ND | ND | 0 |
| Unaffected† | 30 | ND | ND | ND | 0 |
Retroviral pol RNA was detected as described in Materials and Methods. Homologies, ≥90%, to previously described sequences were identified by using the blast algorithm. ND, not detected.
*
P = 0.0012 vs. unaffected, Fisher's exact test (two-tailed).
†
The two groups of Irish (n = 18) and German (n = 12) controls were merged because they did not differ with respect to the outcome of this analysis.