Table 3.
Distribution of retroviral pol transcripts (species homologies ≥90%) in frontal cortex tissue obtained postmortem from unaffected individuals (n = 6) and individuals with a diagnosis of schizophrenia (n = 5)
| Species | No.
homologous clones
|
|
|---|---|---|
| Unaffected | Schizophrenia | |
| HERV-W | 6 (6.7%) | 31 (64.6%)* |
| ERV-MLN | 10 (11.1%) | ND |
| ERV-FRD | 10 (11.1%) | 4 (8.3%) |
| ERV-FTD | ND | 1 (2.1%) |
| HERV-K | 8 (8.9%) | 7 (14.6%) |
| ERV9 | 52 (57.8%) | 1 (2.1%)* |
| HC2 | 2 (2.2%) | 1 (2.1%) |
| Other | 1 (1.1%) | ND |
| No match | 1 (1.1%) | 3 (6.2%) |
| Total clones | 90 | 48 |
Retroviral pol RNA was detected as described in Materials and Methods. Homologies to previously reported sequences were analyzed by using the blastn algorithm. ND, not detected.
*
P < 0.0001, Fisher's exact test (two-tailed).