Figure 3.

Redox imaging biomarkers distinguish between the MDA-MB-231 (aggressive, solid bars) tumor line and the MCF-7 (indolent, open bars) tumor line. Figure 3a shows that only the average of the Fp ratio (core) of the aggressive tumors can distinguish the aggressive from the indolent lines. Figures 3b, 3c show the average concentrations of Fp and NADH relative to the frozen-solution standards for the two tumor groups, respectively. Since there is no distinct core-rim difference identified for the MCF-7 tumors, only the average values of Fp (mean), NADH (mean), and Fp ratio (mean) of the tumor lines were plotted for the preceding figures.