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. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: Lung Cancer. 2011 Jun 12;75(1):15–23. doi: 10.1016/j.lungcan.2011.05.017

Fig. 2. Double-labeling immunoperoxidase staining of ferret lung sections with antibodies for cytokeratin polypeptide 19 (Vector®NovaRed as the substrate) and retinoic acid receptor (RAR)β (DAB plus nickel as the substrate) with methyl green counterstain.

Fig. 2

The left panel represents normal lung sections and the right panel represents lung squamous metaplasia and adjacent bronchioles after 6 weeks of smoke exposure at low magnification x 100 (A, B) and high magnification x 400 (C –F). Arrowheads point to representative nuclei expressing RARβ (stained in black). Arrows point representative areas expressing cytokeratin polypeptide 19 (stained in reddish-purple).