Skip to main content
. Author manuscript; available in PMC: 2012 Oct 13.
Published in final edited form as: J Med Chem. 2011 Sep 15;54(19):6843–6858. doi: 10.1021/jm200794r

Table 1.

Syntheses of substituted pyridine analogs (18a–i) with an isoprenyl side chain.

graphic file with name nihms320741u1.jpg
Comp. R Time % Yield
18a 6-ethyl 30 min 46
18b 4-methyl 30 min 47
18c 3-methyl 9 h 8
18d 5-chloro 30 min 59
18e 5-bromo 10 min 64
18f 5-iodo 1 h 68
18g 3,5-dichloro 1 h 67
18h 5-bromo-6-methyl 30 min 62
18i 3-chloro-5-CF3 45 min 75