Exposure to pyridostigmine bromide dysregulates Cdk5 activity in vivo after a delay period. (a) Effects of systemic exposure to PB following a 4-week delay period after the last treatment on p25 generation and P-T75 DARPP32 in mouse striatum. (b) Delayed effects of systemic exposure to PB on p25 generation in mouse hippocampus. *p=0.0297, **p=0.0065, Student’s t-test, for a, n=6. *p=0.0106, Student’s t-test, for b, n=6.