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. Author manuscript; available in PMC: 2012 Oct 13.
Published in final edited form as: J Med Chem. 2011 Sep 9;54(19):6647–6656. doi: 10.1021/jm200521a

Table 1.

In vitro effects of 14 and 15 on A549 NSCLC cells

14 15
Time (h) IC50 (µM)b EC50 (µM)c IC50 (µM)b EC50 (µM)c
24 17 ± 4 n.d.a 7.6 ± 3 n.d.a
48 15 ± 0.4 24 ± 4 5.2 ±1 19 ± 4
72 13 ± 1 25 ± 4 4.4 ± 2 16 ± 1
a

The viability of A549 cells did not decrease by 50% after 24 h of treatment with 14 or 15.

b

IC50 is concentration of 14 or 15 that decreased cell proliferation by 50% compared to control.

c

EC50 is the concentration of 14 or 15 that decreased cell number by 50% compared to control.