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. 2011 Jul 5;19(10):1842–1848. doi: 10.1038/mt.2011.130

Figure 2.

Figure 2

Optimization of parameters for intrathecal delivery of recombinant human TPP1 (rhTPP1) to the brain. (a) Concentration and dose response using a fixed 40 µl volume with a 10 µl/minute infusion rate. (b) Effect of infusion rate using a fixed 80 µl volume of 10 µg/µl rhTPP1. (c) and (d) Volume and dose response using 10 µg/µl rhTPP1 with a 10 µl/minute infusion rate. TPP1 activity was measured 24 hours after administration to mature (>6 week old) (a,b,c) or young (4–5 week old) (d) Tpp1(−/−) mice.