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. 2011 Jul 19;19(10):1913–1922. doi: 10.1038/mt.2011.132

Figure 2.

Figure 2

Pharmacokinetics of JX-594: acute clearance followed by delayed re-emergence associated with replication and shedding into the blood. (a) Acute genome concentrations in circulation at 15 minutes and 3 hours (patients with genomes below the limit-of-detection are not included). (b) Peak genome concentrations 5–7 days after treatments 1 through 5 (patients with no genomes detected during this time are not included). The delayed reappearance of JX-594 genomes provides evidence for replication and shedding into the blood.