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. 2011 Jul 19;19(10):1913–1922. doi: 10.1038/mt.2011.132

Figure 3.

Figure 3

Biopsy evidence for JX-594 replication and necrosis induction. (a) JX-594 detection by immunohistochemistry (IHC) (red staining) in melanoma cells post-treatment (patient 05007): baseline (negative) and day 5 (positive). Examples of apoptotic and infected cells indicated with red and black arrows, respectively. (b) Hematoxylin and eosin (H&E) stain. Necrosis induction post-treatment (patient 05007): baseline (negative), day 5 (moderate), and day 43 (intense). Bar = 100 µm. Areas of necrosis circled in red.