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. 2011 Aug 2;19(10):1826–1832. doi: 10.1038/mt.2011.154

Figure 4.

Figure 4

Left ventricular hemodynamics was enhanced by adeno-associated virus serotype-9 (AAV-9) microdystrophin therapy. (a) Pressure–volume (PV) loops from eight AAV-treated mdx mice. The age of AAV injection and the duration of therapy are indicated at the bottom of each panel. Representative PV loops from BL10 and mdx mice are depicted in each panel for comparison. Vertical axis, pressure (mm Hg); horizontal axis, volume (µl). (b) Systolic parameters. (c) Diastolic parameters. (d) Overall cardiac function. *Significantly different from the other two groups; cross, significantly different from BL10 only. (e) Kaplan–Meier survival curve within 15 minutes of dobutamine administration. Neither BL10 nor AAV-treated mdx mice died during this period. The survival rate of untreated mdx is significantly lower than that of BL10 and AAV microdystrophin-treated mdx mice (P ≤ 0.0079). N = 7 for BL10, N = 7 for untreated mdx, N = 8 for AAV-treated mdx.