Figure 6.

Envelope-chimeric virus remains oncolytic after systemic administration to MV-immune mice. Subcutaneous MC38CEA tumors were established in C57BL/6 mice with one million cells. Mice received intravenous injections every other day for three days of MV^PNPCDVenv^antiCEA (triangles), MV^PNPantiCEA (diamonds), or mock (circles). (a) Neutralizing anti-MV titers on day 34 after immunization. All mice were seronegative for MV on day 0. (b) Tumor volume for all mice on day 14 post-tumor implantation. CDV, canine distemper virus; CEA, carcinoembryonic antigen; Imm, MV-immunized (filled symbols); Naive, MV-naive (open symbols); MV, measles virus; PNP, purine nucleoside phosphorylase.